Natural Remedies for Gallbladder Stones Gallstones, also known as biliary calculi, are solid deposits that form in the gallbladder due to bile imbalances. They can cause abdominal pain, nausea, and digestive issues. Fortunately, there are many natural remedies that can help prevent and eliminate gallstones without surgery. 1. Watermelon Seed Powder and Olive Oil A traditional effective remedy involves using dried and ground watermelon seeds, combined with olive oil.