Remedies for Hiccups Hiccups are involuntary contractions of the diaphragm, which can be very bothersome. There are several natural remedies that can help stop hiccups. Remedy 1: Vinegar Vinegar can stimulate the vagus nerve and help stop hiccups. How to use: Drink a teaspoon of vinegar very slowly and carefully to avoid choking. Remedy 2: Vinegar with Sugar A mixture of vinegar and sugar can help calm hiccups by stimulating the vagus nerve.