Remedies for Knee Swelling Knee swelling can occur for various reasons, such as sprains, joint inflammation, or fluid accumulation. It can be painful and affect mobility. Fortunately, there are numerous natural remedies that can help reduce swelling and relieve discomfort. Here are some of the most effective solutions for knee swelling. Remedy 1: Hay Flowers Hay flowers are known for their anti-inflammatory and soothing properties, making them an effective natural remedy for swelling and pain in the knees.